Distribution of 18 STR-Haplotypes of Y-Chromosome in Megacities in Connection with Creating Reference Databases

For the senior generations of megacities - Moscow and Novosibirsk, no significant differences by the distribution of 18 STR of Y-chromosome were observed. By 18 STR-haplotypes (DYS389I, DYS389II, DYS390, DYS19, DYS385A, DYS385B, DYS456, DYS437, DYS438, DYS447, DYS448, DYS449, DYS391, DYS392, DYS393, DYS439, DYS635 и DYS576) haplogroups of Y-chromosome were detected with high probability using predictors Whit Athey’s and NEVGEN. ORG for prediction haplogroups of Y-chromosome. Significant differences were revealed between two senior generations by «Southern origin haplotypes», which are introduced into population gene pool with migrant flows. The youngest generation of Moscow, which is under intensive influence of modern migration from the regions of Middle Asia and Northern Caucasus, demonstrates high frequencies of «Southern origin haplogroups». (C3,G2a, G2c, J1, J2, L, O2, O3, Q, R2 and T). Revealed peculiarities of the gene pool of megacities evidence necessity of development special reference databases by DNA-markers of Y-chromosome for each megacity using simultaneously typing of DNA-markers and collecting questionnaire data for detection genetic demographic parameters for inhabitants of megacities, especially, affiliation to particular generation.

Keywords: Megacities, Migration, Y-chromosome Haplogroups, Reference Database.